US 7,741,348 B2 · Bisheterocycle tandem compounds useful as antiviral agents, the uses thereof and the compositions comprising such compounds

Abstract

The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.

Claims4

Dependent claims

A compound having a structure represented by the following structural formula:

wherein,
R2 is hydrogen;
C1-C6 alkyl;
amido;
C1-C4 alkoxycarbonyl;
or carboxyl;
R3 and R6 independently are hydrogen;
C1-C13 alkyl;
halogenated phenyl;
benzyl or halogenated benzyl;
C1-C6 alkyl substituted by C1-C6 alkoxyl;
or C3-C6 cycloalkyl;
R7 is hydrogen, C1-C13 alkyl, or amido.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application

11/886,593Filed 24 Jan 2006

Priority

CN 2005 1 002446818 Mar 2005

Published

US 2008/0306121 A111 Dec 2008

Granted

22 Jun 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

C07D 277/56
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61P 31/16
For RNA viruses: for influenza or rhinoviruses
A61P 31/18
For RNA viruses: for HIV

Bisheterocycle tandem compounds useful as antiviral agents, the uses thereof and the compositions comprising such compounds

Life of this patent

Bisheterocycle tandem compounds useful as antiviral agents, the uses thereof and the compositions comprising such compounds

Life of this patent

Abstract

Claims4