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US 7,741,342 B2Granted
Water-soluble thalidomine derivatives
AssigneesHesheng Zhang, Fengsheng Che
InventorHesheng Zhang
Life of this patent
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Abstract
Thalidomide derivative (I) and their bases or salts are new: where R represents CHR1NR2R3, CHR1NR4C(O)CHR5NR2R3, W or CHR5NR4C(O)W, where R1, R4 and R5 represent independently each other H, C1-4 alkyl, R2 is a C1-4 alkyl, R3 is a C1-4 alkyl, or R2 and R3 together represents 1,3-propylene, 1,4-butylene, 1,5-pentylene, 1,6-hexylene, W represents 4-, 5-, 6-, 7-, or 8-mumbered, saturated or unsaturated heterocycle. The invention also relates to processes of production thereof and the use of thereof as an active pharmaceutical ingredient.
Claims5
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R represents, a heterocycle W or CHR5NR4C(O)W,
- R4 and R5 independently represent H or C1-4 alkyl,
- W represents 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 3-pyrimidyl, 4-pyrimidyl or the heterocycles in formula (II), formula (III), or formula (IV)
- X represents O, S, NR1;
- and
- R1 represents H or C1-4 alkyl.
5 more elements
Dependencies are inferred from the claim text.