Benzo[b]chromeno-naphthyridin-7-one and pyrano[2′,3′:7,8]quino[2,3-b]quinoxalin-7-one compounds

A compound selected from those of formula (I):

• wherein:
• B1 and B2, which may be the same or different, represent, independently of one another, carbon or nitrogen, with the proviso that at least one of B1 or B2 represents nitrogen,
• X and Y represent hydrogen,
• X1 and Y1 represent hydrogen,
• it being understood that, when B1 and/or B2 represent nitrogen, B1 and B2 do not carry substituents Y1 and X1, respectively,
• R1 represents linear or branched (C1-C6)alkyl,
• R2 represents a group selected from hydrogen, linear or branched (C1-C6)alkyl, OR″a;
• —NR′aR′b;
• O-Ta-OR″a;
• —NR″a-Ta-NR′aR′b;
• —NR″a-C(O)-TaH;
• O—C(O)-TaH;
• —O-Ta—NR′aR′b;
• —NR″a-Ta-OR″a;
• —NR″a-Ta-CO2R″a;
• and —NR″a-C(O)-Ta-NR′aR′b,
• wherein:
• Ta represents linear or branched (C1-C6)alkylene,
• R′a and R′b, which may be the same or different, represent, independently of one another, a group selected from hydrogen, linear or branched (C1-C6)alkyl, or R′a and R′b, together with the nitrogen atom carrying them, form a monocyclic, 5- to 7-membered heterocycle optionally containing in the cyclic system a second hetero atom selected from oxygen and nitrogen.
• R″a represents a group selected from hydrogen and linear or branched (C1-C6)alkyl,
• R3 and R4, which may be the same or different, represent, independently of one another, hydrogen or a linear or branched (C1-C6)alkyl group, or
• R3and R4, together with the carbon atom carrying them, form a monocyclic 3- to 6 -membered cyclic group,
• A represents a group of formula:
• —CH(R5)—CH(R6)— wherein:
• R5 and R6, which may be the same or different, represent, independently of one another, a group selected from:
• hydrogen,
• —ORc, NRcRd and SRc, wherein:
• Rc and Rd, which may be the same or different, represent, independently of one another, a group selected from hydrogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl in which the alkyl moiety may be linear or branched,
• or C(O)—Re wherein Re represents a group selected from hydrogen, aryl and NR′″aR′″b wherein R′″a and R′″b are identical and represent hydrogen or
• R′″a and R′″b, together with the nitrogen atom carrying them, form a monocyclic, 5- to 7-membered heterocycle optionally containing in the cyclic system a second hetero atom selected from oxygen and nitrogen,
• W1—C(W2)—U—V wherein:
• W1 represents oxygen, sulphur or NRc wherein Rc is as defined hereinbefore,
• W2 represents oxygen or sulphur,
• U represents linear or branched (C1-C8)alkylene or linear or branched (C2-C8) alkenylene,
• V represents a group selected from:
• hydrogen,
• aryl,
• ORc, CO2Rc, CORc, CONR′aR′b, NRcRd, N(Rc)—CO2R′c, N(Rc)—COR′c, wherein R′a, R′b, Rc and Rd are as defined hereinbefore and R′c represents a group selected from hydrogen, linear or branched (C1-C6)alkyl, aryl, and aryl-(C1-C6)alkyl in which the alkyl moiety may be linear or branched,
• it being understood that
• U represents a bond when W2 does not represent an oxygen atom and when simultaneously V does not represent a group selected from hydrogen, aryl and NH2,
• —W1—C(W2)—W3-T1 wherein:
• W1 and W2 are as defined hereinbefore,
• W3 represents oxygen, sulphur, or NRc wherein Rc is as defined hereinbefore,
• T1 represents a group selected from:
• hydrogen,
• linear or branched (C1-C6)alkyl,
• linear or branched (C2-C6)alkenyl,
• aryl,
• aryl-(C1-C6)alkyl in which the alkyl moiety may be linear or branched, and
• linear or branched (C1-C6)alkylene or linear or branched (C2-C6)alkenylene, each being substituted by a group selected from ORc and NR′aR′b wherein Rc, R′a and R′b are as defined hereinbefore,
• —W1—S(O)n—W3-T1 wherein:
• W1, W3 and T1 are as defined hereinbefore,
• n represents an integer from 1 and 2,
• W1-S(O)n-T1 wherein W1, T1 and n are as defined hereinbefore,
• —C(W2)-T1 wherein W2 and T1 are as defined hereinbefore, or R5 and R6, together form a group selected from:
• wherein Z represents oxygen or sulphur;
• —O—(CH2)m—O— wherein m represents an integer of from 1 to 4 inclusive;
• and
• wherein B represents a single bond, linear or branched (C1-C6)alkylene or linear or branched (C2-C6)alkenylene;
• or R5 and R6, together with the carbon atoms carrying them, form oxirane or aziridine, optionally substituted on the nitrogen atom by a linear or branched (C1-C6) alkyl,
• and addition salts thereof with a pharmaceutically acceptable acid or base,
• it being understood that:
• “aryl” may be “phenyl” or “naphthyl” each of those groups being optionally substituted by one or more, identical or different, substituents selected from linear or branched (C1-C6) alkyl, linear or branched (C2-C6)alkenyl, hydroxy, halogen, carboxy, nitro, amino, linear or branched (C1-C6)alkylamino or (C1-C6)dialkylamino wherein each alkyl moiety may be linear or branched, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6) acyl and linear or branched (C1-C6)alkylcarbonyloxy.