Compounds and methods for inhibiting selectin-mediated function
AssigneeGlycoMimetics, Inc.
InventorsJohn L Magnani, John T Patton, Jr., Leonard M Williams
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Abstract
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof linked to a carbohydrate or glycomimetic.
Claims4
A compound or physiologically acceptable salt thereof, consisting of a benzyl amino sulfonic acid (BASA) linked to a glycomimetic wherein the glycomimetic binds a selectin and is a glycomimetic of sialyl Lex or sialyl Lea;
- and wherein the BASA is:
- where R1 and R2 are hydrogen and one is displaced upon linkage of the BASA via N to the glycomimetic, and M is a pharmaceutically acceptable counterion.
Dependencies are inferred from the claim text.