RNA aptamers and methods for identifying the same
AssigneeDuke University
InventorsBruce A. Sullenger, Christopher P. Rusconi
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Abstract
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA aptamers are also disclosed.
Claims58
An RNA aptamer that binds to the coagulation pathway factor X or Xa wherein the aptamer comprises a first consensus sequence comprising a nucleotide sequence UACUU and wherein the aptamer comprises a secondary structure consisting of, in a 5′ to 3′ direction, a first stem, a first loop, a second stem and a second loop.
A pharmaceutical composition comprising a therapeutically effective amount of an RNA aptamer which binds to the coagulation pathway factor X or Xa wherein the aptamer comprises a first consensus sequence comprising a nucleotide sequence UACUU and wherein the aptamer comprises a secondary structure consisting of, in a 5′ to 3′ direction, a first stem, a first loop, a second stem and a second loop.
A method of modulating the biological activity of a coagulation pathway factor X or Xa comprising administering to a host an RNA aptamer that binds to the coagulation pathway factor X or Xa, wherein the aptamer comprises a first consensus sequence comprising a nucleotide sequence UACUU and wherein the aptamer comprises a secondary structure consisting of, in a 5′ to 3′ direction, a first stem, a first loop, a second stem and a second loop.
Dependencies are inferred from the claim text.