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US 7,741,290 B2Granted
Method of preventing progression of hypertension-induced heart failure with PKC peptides
AssigneeThe Board of Trustee of The Leland Stanford Juinior University
InventorsDaria D. Mochly-Rosen, Koichi K. Inagaki
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Abstract
Methods are described for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension. The methods involve administering an εPKC, β1PKC, or βIIPKC peptide inhibitor, examples of which are provided.
Claims6
A method for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension, comprising:
- administering to the subject a therapeutically effective amount of an εPKC peptide inhibitor, wherein the εPKC peptide inhibitor is from the V1 domain of εPKC.
Dependencies are inferred from the claim text.