ApO2 ligand/TRAIL formulations
AssigneeGenentech, Inc.
InventorsTanya P. Lin, Zahra Shahrokh, Heather Flores, Roger Pai, Timothy C. Matthews
Life of this patent
Estimating the term…
Abstract
The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
Claims32
A formulation of Apo-2 ligand, comprising Apo-2 ligand, about 0.2M to about 0.5M arginine salt, buffer, and surfactant selected from the group consisting of a polysorbate or poloxamer, wherein said formulation is storage-stable and has a pH of about 6 to about 9.
A storage-stable, lyophilized formulation of Apo-2 ligand, comprising about 1 mg/ml to about 20 mg/ml Apo-2 ligand, about 0.2 M to about 0.5M arginine salt, buffer, and surfactant, wherein said formulation has a pH of about 6 to about 9.
A storage-stable formulation of Apo-2 ligand, comprising about 1 mg/ml to about 20 mg/ml Apo-2 ligand, about 0.2M to about 0.5 M sodium sulphate, buffer, and surfactant, wherein said Apo-2 ligand comprises crystallized protein and said formulation has a pH of about 6 to about 9.
A storage-stable, lyophilized formulation of Apo-2 ligand, comprising about 1 mg/ml to about 20 mg/ml Apo-2 ligand, about 0.4 M to about 0.5M arginine succinate, Tris buffer, and polysorbate surfactant, wherein said formulation has a pH of about 7 to about 7.5.
Dependencies are inferred from the claim text.