# US 7,741,276 B2 · Use of interleukin-18 inhibitors to inhibit tumor metastasis

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- Number: US 7,741,276 B2
- Document ID: US7741276B2
- Status: Granted
- Kind: B2
- Application number: 11/825,548
- Filed: 2007-07-06
- Published: 2008-01-03
- Granted: 2010-06-22
- Earliest claimed: 1999-07-22
- Assignees: Ares Trading S.A.
- Inventors: Charles Dinarello
- Web page: https://patentgrep.com/patent/US7741276B2

## CPC

- A61K 38/20: Interleukins [IL]
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 38/07: Tetrapeptides
- A61K 38/17: from animals; from humans {(enzyme inhibitors A61K38/005)}
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- C07K 16/244: {Interleukins [IL]}
- A61K 2039/505: {comprising antibodies}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Use of IL-18 inhibitors in tumor metastasis is disclosed.

## Claims

### Claim 1

A method of inhibiting melanoma cell hepatic and lung tissue metastasis in a subject in need thereof comprising administering to the subject a therapeutically effective amount of IL-18BP in a pharmaceutically acceptable carrier.