Agents and use thereof
AssigneeLipopeptide AB
InventorsMona Ståhle, Johan Heilborn, Margareta Frohm Nilsson, Gunter Weber
Life of this patent
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Abstract
The present invention provides agents for inhibiting the proliferation of cancer cells, wherein the agent inhibits the biological activity of hCAP18/LL-37. In a preferred embodiment, the agent alters the transcription, translation and/or binding properties of hCAP18/LL-37. Preferably, the agent is selected from the group consisting of short interfering RNA (siRNA) molecules, antisense oligonucleotides and compounds with binding affinity for hCAP18/LL-37. The invention further provides methods for inhibiting the proliferation of cancer cells in a patient, as well as methods and kits for diagnosing cancer.
Claims7
A method for inhibiting the proliferation of cancer cells in a patient, the method comprising administering to the patient a polypeptide which inhibits hCAP18/LL-37 by inhibiting the binding properties of hCAP18/LL-37, wherein the cancer cells are breast cancer cells.
Dependencies are inferred from the claim text.