Exendins and exendin agonists for weight reduction and obesity
AssigneeAmylin Pharmaceuticals, Inc.
InventorsAndrew A. Young, Sunil Bhavsar, Bronislava Gedulin
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Abstract
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
Claims44
A method for reducing body weight in a human in need thereof comprising identifying a human in need of a reduction in body weight, and administering to the human a therapeutically effective amount of an exendin-4 peptide comprising the amino acid sequence of SEQ ID NO:
- 2 to reduce body weight.
A method for reducing body weight in a human in need thereof comprising identifying a human in need of a reduction in body, and administering to the human a therapeutically effective amount of an exendin peptide or an exendin agonist analog peptide to reduce body weight.
A method for treating obesity in a human in need thereof comprising identifying a human in need of treatment for obesity, and administering to the human a therapeutically effective amount of an exendin-4 peptide comprising the amino acid sequence of SEQ ID NO:
- 2 to treat obesity.
A method for treating obesity in a human in need thereof comprising identifying a human in need of treatment for obesity, and administering to the human a therapeutically effective amount of an exendin peptide or an exendin agonist analog peptide to treat obesity.
A method for reducing body weight in a human in need thereof comprising identifying a human in need of a reduction in body weight, and subcutaneously administering to the human from 0.1 μg/kg/day to 10 μg/kg/day of an exendin-4 peptide comprising the amino acid sequence of SEQ ID NO:
- 2 to reduce body weight.
A method for treating obesity in a human in need thereof comprising identifying a human in need of treatment for obesity, and subcutaneously administering to the human from 0.1 μg/kg/day to 10 μg/kg/day of an exendin-4 peptide comprising the amino acid sequence of SEQ ID NO:
- 2 to treat obesity.
Dependencies are inferred from the claim text.