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US 7,741,085 B2Granted
Compound WS727713
AssigneeAstellas Pharma Inc.
InventorsTakanao Otsuka, Hirotsugu Ueda, Keiko Fujie, Hideyuki Muramatsu, Michizane Hashimoto, Shigehiro Takase
Life of this patent
Estimating the term…
Abstract
The present invention relates to a compound WS727713, useful as a modulator of melanocortin receptors, and a process for its production by culturing in a culture medium the actinomycetes strain of the genus Pseudonocardia, deposit number FERM BP-7570 and recovering the compound.
Claims3
A substantially pure WS727713 compound having the following properties:
- a) Molecular formula:
- C30H44N8O8;
- b) 1H Nuclear magnetic resonance spectrum:
- (500 MHz, DMSO-d6) δ 9.76 (1H, s, exchangeable), 8.76 (1H, d, J=7.5 Hz, exchangeable), 8.23 (1H, d, J5 Hz, exchangeable), 7.76 (1H, dd, J=8.5 and 3 Hz, exchangeable), 7.25-7.17 (5H, m), 5.71 (1H, dd, J=10.5 and 5 Hz), 5.08 (1H, dd, J=11 and 4 Hz, exchangeable), 5.03 (1H, m), 4.99 (1H, m), 4.92 (1H, m), 4.85 (1H, m), 4.83 (1H, d, J=3 Hz, exchangeable), 4.76 (1H, br d, J=12 Hz, exchangeable), 4.12 (1H, dd, J=16.5 and 8.5 Hz), 3.65 (1H, dd, J=16.5 and 3 Hz), 3.58 (1H, m), 3.07 (1H, dd, J=13.5 and 8.5 Hz), 2.94 (1H, br d, J=13 Hz), 2.86 (1H, dd, J=13.5 and 6 Hz), 2.73-2.68 (2H, m), 2.58 (1H, m), 2.24 (1H, br d, J13 Hz), 2.08 (1H, br d, J=14 Hz), 1.88 (1H, m), 1.67 (1H, m), 1.55 (1H, m), 1.42-1.36 (2H, m), 1.21 (1H, m), 1.19 (3H, d, J=7 Hz), 1.09 (1H, m), 0.76 (3H, d, J=6.5 Hz), 0.75 (3H, d, J=6.5 Hz);
- c) 13C Nuclear magnetic resonance spectrum:
- (125 MHz, DMSO-d6) δ 173.8 (s), 171.7 (s), 170.4 (s), 169.8 (s), 169.1 (s), 167.6 (s), 137.2 (s), 129.2 (d)x2, 128.0 (d) x2, 126.3 (d), 60.2 (d), 53.2 (t), 51.1 (d), 50.8 (d), 49.6 (d), 47.4 (d), 47.0 (t), 44.7 (d), 41.2 (t), 36.4 (t), 35.4 (t), 33.2 (t), 23.6 (d), 23.5 (t), 23.1 (q), 21.7 (q), 21.0 (t), 15.8 (q).
3 more elements
Dependencies are inferred from the claim text.