Detection and diagnosis of smoking related cancers
AssigneeBoard of Regents, The University of Texas System
InventorsRuth Katz, Feng Jiang
Life of this patent
Estimating the term…
Abstract
Gene probes for specific regions of chromosome 3 (3p21.3) and chromosome 10 (10q22) have been found to be tools for the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluorescence in situ hybridization (FISH), and used to stratify smokers into high and low risk groups, as well as determine a patients susceptibility to the development of smoking related cancers.
Claims21
A method for identifying a subject at risk for the development, recurrence, or metastasis of non-small cell lung cancer comprising:
- (a) obtaining a lung test sample from a human subject;
- (b) providing a 10q22 DNA probe;
- (c) contacting said probe with said test sample;
- (d) analyzing DNA from said test sample;
- (e) detecting a loss of heterozygosity in the hybridization of said probe to said DNA, as compared to a centromeric DNA probe for chromosome 10;
- and
- (f) identifying the subject at risk for the development, recurrence, or metastasis of non-small cell lung cancer when loss of heterozygosity is detected.
A method for predicting the progression or metastasis of non-small cell carcinoma in a subject comprising:
- (a) obtaining a lung test sample from a human subject;
- (b) providing a 10q22 DNA probe;
- (c) contacting said probe with said test sample;
- (d) analyzing DNA from said test sample;
- (e) detecting a loss of heterozygosity in the hybridization of said probe to said DNA, as compared to a centromeric DNA probe for chromosome 10;
- and
- (f) predicting the development, recurrence, or metastasis of non-small cell carcinoma in the subject.
A method for identifying a subject at risk for the development, recurrence, or metastasis of non-small cell lung cancer comprising:
- (a) obtaining a test sample from a human subject;
- (b) providing a 10q22 DNA probe;
- (c) contacting said probe with said test sample;
- (d) analyzing DNA from said test sample;
- (e) detecting a loss of heterozygosity in the hybridization of said probe to said DNA, as compared to a centromeric DNA probe for chromosome 10;
- and
- (f) identifying the subject at risk for the development, recurrence, or metastasis of non-small cell lung cancer when loss of heterozygosity is detected.
Dependencies are inferred from the claim text.