Method of diagnosing lung cancer using BGS42
AssigneeBristol-Myers Squibb Company
InventorsJohn N. Feder, Shujian Wu, Thomas C. Nelson, Liana M. Lee
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Abstract
The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Claims10
A method of diagnosing lung tumors comprising:
- a) determining the expression level of a polypeptide comprising the sequence of SEQ ID NO:2 in a lung test sample;
- and
- b) comparing said expression level of said polypeptide from a normal lung sample with the expression level of said polypeptide in said test sample;
- wherein a decreased expression level of said polypeptide in said test sample relative to the expression level of said polypeptide in said normal sample is indicative of a lung tumor or a predisposition to a lung tumor.
Dependencies are inferred from the claim text.