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US 7,740,954 B2Granted
Reactive dendrimers
AssigneesIsis Innovation Limited, University Court of the University of St Andrews
InventorsPaul Leslie Burn, Ifor David William Samuel, Michael Frampton
Life of this patent
Estimating the term…
Abstract
A process for modifying at least one dendron that is intended to form part of a dendrimer is disclosed. One reacts at least one reactable unsaturated group in a chemoselective manner to form a less unsaturated group. Also disclosed is a process for modifying dendrimers in a similar manner.
Claims26
A process for modifying at least one dendron intended to form part of a dendrimer, said dendron having the formula:
- FO(dendrite−Qa)y
- wherein FO is a functional group attached, either directly or via a linking group which can contain one or more reactable unsaturated units, to the first branching atom or group of the dendrite, each “dendrite” which may be the same or different is a dendrite which contains branching atoms or groups and optionally linking groups and comprises at least said first branching atom or group which must have, in addition to FO, 2 or more groups attached and in which the distal group of each arm of the dendrite is an aryl or heteroaryl group, at least one of said dendrite or, if present, the linking group to FO containing one or more reactable unsaturated units, y is 1 or more, Q is a surface group and a is 0 or an integer, which comprises reacting at least one said reactable unsaturated group in a chemoselective manner to form a less unsaturated group, with the proviso that the process does not comprise hydrogenating a dendron of the formula
- where R is 2-ethylhexyloxy.
A process for modifying a dendrimer of the formula:
- CORE−[dendrite−Qa]x
- wherein Q and a are as defined above, x is one or 2 or more such that when x is more than one each dendrite−Qa can be the same or different and CORE represents an atom or group and CORE terminates at the single bond to the first branching atom or group in the or each “dendrite”, each “dendrite” which may be the same or different and is a dendrite which contains branching atoms or groups and optionally linking groups, at least one of CORE and dendrite comprising at least one reactable unsaturated group, provided that the distal group of each arm of the or each dendrite
- is an aryl or heteroaryl group, which comprises reacting at least one reactable unsaturated group to form a less unsaturated group in a chemoselective manner.
Dependencies are inferred from the claim text.