Polymeric carrier for delivery of small interfering RNA
AssigneeUniversity of Utah Research Foundation
InventorsWon Jong Kim, Sung Wan Kim
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Abstract
A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.
Claims11
A method of making a complex, the method comprising mixing a small interfering RNA with a conjugate comprising a cholesterol residue covalently bonded to oligoarginine through a formate residue linker, thereby forming the complex, wherein the conjugate is represented by the formula:
- wherein n is about 4 to 16.
A composition comprising a mixture of a small interfering RNA and a conjugate comprising a cholesterol residue covalently bonded to oligoarginine through a formate residue linker, wherein the conjugate is represented by the formula:
- wherein n is about 4 to 16.
Dependencies are inferred from the claim text.