Organo-gel formulations for therapeutic applications
AssigneeMediQuest Therapeutics, Inc.
InventorFrederick J. Dechow
Life of this patent
Estimating the term…
Abstract
A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.
Claims23
A composition suitable for the delivery of at least one cosmetic agent or pharmaceutical agent or both through the skin of a mammal, which comprises two biocompatible organic solvents, 6 to 30% by weight of lecithin, 0.5 to 15% by weight of at least one or more surfactant, wherein said surfactant comprises a docusate, 40 to 65% by weight water, 1 to 15% by weight of urea and 0.05 to 5% by weight of a thickener;
- wherein the organic solvents comprise isopropyl myristate and propylene glycol;
- and wherein the composition comprises 2 to 30% of the isopropyl myristate and 2 to 20% of the propylene glycol.
A method of making a composition suitable for cutaneous delivery of a pharmaceutically active substance which comprises:
- a. dissolving 6 to 30% by weight of lecithin, at least in two biocompatible organic solvents comprising isopropyl myristate and propylene glycol;
- b. adding 0.5 to 15% of one or more surfactants to the composition of step (a), wherein the one or more surfactants comprise a docusate;
- c. dissolving a pharmaceutically active compound in the solvent-lecithin, surfactant mixture of step (b);
- d. adding 1 to 15% by weight of urea and 0.05 to 5% by weight of a thickener to water;
- and
- e. combining the composition from c and d and optionally adjusting the pH to about 5.5 to about 7.5;
- wherein the amount of water is 40 to 65% by weight, the amount of isopropyl myristate is 2 to 30% by weight, and the amount of propylene glycol is 2 to 20% by weight.
A composition suitable for cutaneous delivery of a pharmaceutically active substance prepared by a method which comprises:
- a. dissolving 6 to 30% by weight of lecithin, at least in two biocompatible organic solvents comprising isopropyl myristate and propylene glycol;
- b. adding 0.5 to 15% by weight of one or more surfactants to the composition of step (a);
- c. dissolving a pharmaceutically active compound in the solvent-lecithin, surfactant mixture of step (b);
- d. adding 1 to 15% by weight of urea and 0.05 to 5% by weight of a thickener to water;
- and
- e. combining the composition from c and d and optionally adjusting the pH to about 5.5 to about 7.5;
- wherein the one or more surfactants comprise a docusate, the amount of water is 40 to 65% by weight, the amount of the isopropyl myristate is 2 to 30%, the amount of the propylene glycol, is 2 to 20.
Dependencies are inferred from the claim text.