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US 7,740,868 B2Granted
Activatable clostridial toxins
AssigneeAllergan, Inc.
InventorsLance E. Steward, Joseph Francis, Ester Fernandez-Salas, Sanjiv Ghanshani, Marcella A. Gilmore, Shengwen Li, J. Oliver Dolly, Kei Roger Aoki
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Abstract
Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
Claims34
A recombinant single-chain polypeptide comprising:
- a) a first domain comprising a binding element comprising a melanocortin peptide able to preferentially interact with a melanocortin receptor under physiological conditions;
- b) a second domain comprising a translocation element comprising a Clostridial neurotoxin translocation domain able to facilitate the transfer of a Clostridial toxin light chain across a vesicular membrane;
- c) a third domain comprising a therapeutic element comprising a Clostridial neurotoxin light chain having biological activity when released into the cytoplasm of said target cell;
- and
- d) a fourth domain comprising an exogenous protease cleavage site.
2 more elements
Dependencies are inferred from the claim text.