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US 7,740,848 B2Granted
Method of treatment of skin inflammation
AssigneeSchering Corporation
InventorsRobert A. Kastelein, Terrill K. McClanahan, Erin Murphy, Jason R. Chan
Life of this patent
Estimating the term…
Abstract
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
Claims7
A method of treating skin inflammation in a subject comprising:
- a) measuring IL-19 in a non-lesional psoriatic skin sample from said subject using real-time PCR,
- b) determining that said subject exhibits at least 20-fold higher expression of IL-19 compared to a normal skin sample, and
- c) administering an antagonist of IL-23 to effectively treat skin inflammation in said subject wherein said antagonist is an antibody or binding fragment thereof.
Dependencies are inferred from the claim text.