Variant Fc regions
AssigneeApplied Molecular Evolution, Inc.
InventorsBarrett Allan, Weidong Jiang, Ying Tang, Jeffry Dean Watkins
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Abstract
The present invention provides humanized anti-CD20 antibodies comprising a human IgG1 Fc region comprising an isoleucine at position 247 and a glutamine at position 339 as well as nucleic acids encoding the antibodies and methods of using the antibodies for treating lymphoma. Furthermore, the invention provides compositions comprising the antibodies and methods of producing them.
Claims13
An anti-CD20 antibody comprising a light chain and a heavy chain, wherein the amino acid sequence of the light chain consists of SEQ ID NO:
- 29 and the amino acid sequence of the heavy chain consists of SEQ ID NO:
- 31.
An anti-CD20 antibody comprising two light chains and two heavy chains, wherein the amino acid sequence of each light chain consists of SEQ ID NO:
- 29 and the amino acid sequence of each heavy chain consists of SEQ ID NO:
- 31.
An isolated nucleic acid comprising a nucleic acid selected from the group consisting of:
- (a) a nucleic acid encoding a heavy chain wherein the amino acid sequence of the heavy chain consists of SEQ ID NO:31;
- and
- (b) a nucleic acid encoding a light chain and a heavy chain wherein the amino acid sequence of the light chain consists of SEQ ID NO:29 and wherein the amino acid sequence of the heavy chain consists of SEQ ID NO:31.
Dependencies are inferred from the claim text.