Inhibitors of angiopoietin-like 4 protein, combinations, and their use
AssigneeGenentech, Inc.
InventorsHanspeter Gerber, Napoleone Ferrara, Xiao Huan Liang
Life of this patent
Estimating the term…
Abstract
Modulators of angiopoietin-like 4 protein are provided along with methods for their use in the treatment of diseases and pathological conditions. Combinations of ANGPTL4 antagonists and other therapeutics, e.g., anti-cancer agents, and methods of their use in the treatment of mammals susceptible to or diagnosed with cancer, or with relapse tumor growth or relapse cancer cell growth are also provided.
Claims19
A method of blocking or reducing growth and inhibiting metastasis of breast cancer, said method comprising administering to a subject diagnosed with breast cancer an effective amount of a vascular endothelial growth factor (VEGF) antagonist and an effective amount of an angiopoietin-like 4 protein (ANGPTL4) antagonist,
- wherein the combined effective amounts block or reduce growth and inhibit metastasis of the breast cancer.
A method of blocking or reducing relapse growth of breast cancer in a subject, the method comprising:
- administering to the subject an effective amount of an angiopoietin-like 4 (ANGPTL4) antagonist, wherein the subject was or is concurrently undergoing cancer therapy with a vascular endothelial growth factor (VEGF) antagonist, and wherein the administration of the effective amount of the ANGPTL4 antagonist blocks or reduces the relapse growth of breast cancer.
Dependencies are inferred from the claim text.