High activity mutants of butyrylcholinesterase for cocaine hydrolysis
AssigneeUniversity of Kentucky Research Foundation
InventorsChang-Guo Zhan, Fang Zheng, Wenchao Yang
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Abstract
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Claims5
A butyrylcholinesterase polypeptide variant comprising the amino acid sequence of SEQ ID NO:
- 2.
A pharmaceutical composition comprising a butyrylcholinesterase polypeptide variant comprising the amino acid sequence of SEQ ID NO:
- 2 and a suitable pharmaceutical carrier.
Dependencies are inferred from the claim text.