Integrated CMOS-compatible biochip

A method of manufacturing a device used for analysis of a fluid sample, the method comprising:

• integrally forming a processor in a substrate, wherein the processor is configured to analyze a test result from a test performed on the fluid sample;
• forming a trench in the substrate to form a reagent reservoir configured to contain a reagent, a mixing reservoir including a chamber configured to receive and mix the fluid sample and the reagent to form a mixture, a channel, and a sample reservoir configured to receive the fluid sample, wherein the channel is formed to provide fluid communication between the reagent reservoir, the mixing reservoir, and the sample reservoir;
• placing at least a portion of a sensor within the chamber, the sensor configured to sense an electrical charge of the mixture that includes the fluid sample within the chamber to generate the test result based on sensing the electrical charge, and to transmit the test result to the processor;
• and
• coupling the processor to the sensor.

A method of manufacturing a device used for analysis of a fluid sample, the method comprising:

• forming a trench in a substrate to form a sample reservoir configured to receive the fluid sample, a reagent reservoir configured to contain a reagent, a mixing reservoir including a chamber configured to receive and mix the fluid sample and the reagent to form a mixture, and channels configured to provide fluid communication between the sample reservoir, the mixing reservoir, and the reagent reservoir;
• integrating doped silicon into the substrate proximate the trench;
• placing at least a portion of a sensor within the chamber, the sensor configured to sense, within the chamber, a measurable property of a mixture that includes the fluid sample in order to generate the test result, wherein the measurable property is a property selected from a group of properties that includes a chemical property of the mixture, a physical property of the mixture, and an electrical property of the mixture;
• coupling a processor to the sensor, wherein the processor is integrally formed in the substrate;
• and
• coupling a channel controller to the doped silicon and to a power source, wherein the channel controller is configured to provide an electrical bias between a first channel of the channels and a second channel of the channels to move the fluid sample from the sample reservoir to the mixing reservoir.