Method and apparatus for automated optimization of treatment plans

A system for adjusting infusion parameters that provide coverage of a selected target volume in tissue for direct infusion of a fluid, comprising:

• an imaging device for obtaining image data;
• a processor operatively coupled to the imaging device and configured to obtain patient-specific medical and/or anatomical image data from the imaging device;
• a data bank operatively coupled to the processor and including information for calculating infusion relevant parameters from the imaging data obtained from the imaging device;
• and
• an infusion system including at least one delivery device and at least one injecting mechanism, said injecting mechanism controllable by the processor based on the information obtained from the imaging device and/or the data bank so as to cover the target volume with a substance delivered or infused by the at least one delivery device, wherein said infusion system is configured to determine the coverage of the selected target volume by the substance by calculating an optimal packing of spheres or cylinders in the selected target volume.

A device for planning an infusion of a substance into a target volume, comprising:

• a first input for receiving infusion parameters for the target volume;
• a second input for receiving patient specific data pertaining to the target volume;
• a processor and memory;
• and
• computer executable instructions stored in memory and executable by the processor, wherein when executed by the processor, the computer executable instructions cause the processor to use the infusion parameters and patient specific data to determine a coverage of the substance in the target volume by calculating an optimal packing of spheres or cylinders in the target volume.