Osteointegrative interface for implantable prostheses and a method for the treatment of the osteointegrative interface

A biomimetic osteointegrative interface comprising:

• a substrate (3) of biocompatible material selected from the group consisting of:
• titanium, tantalum, and alloys thereof, the substrate having a surface (3bis);
• the interface comprising, on the surface (3bis) of the substrate (3), a first layer (4) having a first concentration of oxide of the biocompatible material, selected from the group consisting of:
• titanium oxide, tantalum oxide and oxide of alloys of said titanium and tantalum that is enriched with a second concentration of phosphorus and with a third concentration of calcium, the ratio between the concentration of calcium and the concentration of phosphorus being greater than two;
• the biomimetic osteointegrative interface (1) further comprising:
• a second layer (5) having a first surface (10) in contact with the first layer (4), and a second surface (11), the second layer (5) having a fourth concentration of oxide that is the same oxide present in the first layer and enriched with a fifth concentration of calcium and a sixth concentration of phosphorus, the fourth concentration being less than the fifth and the sixth concentrations and the ratio between the fifth concentration of calcium and the sixth concentration of phosphorus being no less than three;
• and
• wherein the second layer (5) is hydrated and has —OH hydroxyl chemical coupling groups suitable for forming a plurality of nucleation centers (12).