Method for producing 2-hydroxyester compound
AssigneeNippoh Chemicals Co., Ltd.
InventorsIchiro Kozono, Naoki Fujiwara, Daisuke Hino
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AssigneeNippoh Chemicals Co., Ltd.
InventorsIchiro Kozono, Naoki Fujiwara, Daisuke Hino
Estimating the term…
A simple and easy-to-use method for producing a 2-hydroxyester compound using a cyanohydrin compound, as a raw material, is provided. A method for producing a 2-hydroxyester compound represented by the general formula (1) (provided that ethyl 2-hydroxy-4-phenylbutyrate is excluded), wherein an acid is introduced into a mixture of a cyanohydrin compound represented by the general formula (2), an alcohol, an organic solvent and water: (Chemical Formula 1) R1—CH(OH)—COOR2 (1) R1—CH(OH)(CN) (2) wherein, R1 is a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 12 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom, a substituted or unsubstituted alicyclic hydrocarbon group having 3 to 12 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom, and a substituted or unsubstituted aryl group or aralkyl group having 3 to 14 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom; and R2 is an alkyl group having 1 to 12 carbon atoms, which may contain an oxygen atom, a sulfur atom or a nitrogen atom.
A method for producing a 2-hydroxyester compound represented by the general formula (1) (provided that ethyl 2-hydroxy-4-phenylbutyrate is excluded), comprising introducing an acid into a mixture of a cyanohydrin compound represented by the general formula (2), an alcohol, an organic solvent and water to carry out a reaction in a single stage and without isolating an intermediate:
A method for producing a 2-hydroxyester compound represented by the general formula (1) (provided that ethyl 2-hydroxy-4-phenylbutyrate is excluded), which comprises:
Dependencies are inferred from the claim text.