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US 7,737,284 B2Granted
Synthesis of temozolomide and analogs
AssigneeSchering-Plough Corporation
InventorsShen-Chun Kuo, Janet L. Mas, Donald Chen-tung Hou
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Abstract
This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.
Claims1
A process for the preparation of a compound of the Formula II,
- wherein R is an alkyl group having from 1 to 6 carbon atoms, the process comprising:
- (I) condensing the compound of Formula 14,
- (H2N.CO.CH(NH2).CN) Formula 14,
- with a compound of Formula 7a,
- R.NH.CO.NH.CH:N.CO.NH.R Formula 7a, wherein
- “R” is as defined above, in an inert organic solvent;
- or
- (ii) condensing the compound of Formula 14,
- (H2N.CO.CH(NH2).CN) Formula 14,
- with an alkyl urea of the formula R—NH(CO)NH2, where “R” is as defined above, and an alkyl orthoformate of the formula (R1O)3CH, wherein “R1” is an alkyl group having from 1 to 6 carbon atoms in an inert organic solvent.
7 more elements
Dependencies are inferred from the claim text.