Methods and compositions for regulating HDAC4 activity
AssigneeDuke University
InventorsTso-Pang Yao, Todd Cohen, Tomasa Barrientos De Renshaw
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Abstract
The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are methods and compositions for treating muscle atrophy and/or inflammation by inhibiting HDAC4 activity.
Claims20
A method of increasing slow/oxidative fiber formation in skeletal muscle, comprising contacting skeletal muscle cells with an inhibitor of HDAC4 activity.
A method of decreasing nicotinic acetylcholine receptor (nAChR) alpha, beta, and/or gamma subunit expression in a muscle cell, comprising contacting the cell with an inhibitor of HDAC4 activity.
A method of treating muscular atrophy in a subject, comprising administering to the subject an effective amount of an inhibitor of HDAC4 activity.
A method of treating diabetes in a subject, comprising administering to the subject an effective amount of an inhibitor of HDAC4 activity.
A method of decreasing inflammatory cytokine activity in a cell, wherein the inflammatory cytokine is selected from the group consisting of TNF alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-2, interleukin-6 and any combination thereof, comprising contacting the cell with an inhibitor of HDAC4 activity.
A method of decreasing c-jun and/or c-fos expression in a cell, comprising contacting the cell with an inhibitor of HDAC4 activity.
A method of reducing inflammation in a subject, comprising administering to the subject an effective amount of an inhibitor of HDAC4 activity.
Dependencies are inferred from the claim text.