Chlamydia polypeptides and corresponding DNA fragments and uses thereof
AssigneeSanofi Pasteur Limited
InventorsAndrew D. Murdin, Raymond P. Oomen, Joe Wang, Pamela Dunn
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Abstract
The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98 kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.
Claims26
An isolated nucleic acid molecule comprising a nucleotide sequence which encodes the polypeptide SEQ ID NO:3 or 4.
A vaccine vector comprising a nucleotide sequence which encodes the polypeptide of SEQ ID NO:3 or 4, wherein the nucleotide sequence is operably linked to a promoter functional in a mammalian cell, wherein the vaccine vector is unable to replicate in mammalian cells and unable to integrate in a mammalian genome.
Dependencies are inferred from the claim text.