Controlled release therapeutic wound dressings
AssigneeSystagenix Wound Management (US), Inc.
InventorsBreda Mary Cullen, Derek Walter Silcock, Jonathan Warrick
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Abstract
A wound dressing comprising: a therapeutic agent selected from the group consisting of antimicrobial substances, pain relieving substances, protease inhibitors, and mixtures thereof; and a barrier layer for initially separating the therapeutic agent from a wound fluid in use, wherein the barrier layer comprises a substrate for an enzyme selected from the group consisting of proteases, kallikrein and tissue-plasminogen activator. Preferably the substrate comprises a substrate for elastase or a collagenase. The barrier layer breaks down in infected or chronic wounds, thereby releasing the therapeutic substance selectively into such wounds.
Claims17
A wound dressing comprising:
- a therapeutic agent selected from the group consisting of antimicrobial substances, pain relieving substances, protease inhibitors, and mixtures thereof;
- and
- a wound contacting barrier layer for initially separating the therapeutic agent from a wound fluid, said barrier layer comprising a substrate for an enzyme from an infected or chronic wound selected from the group consisting of proteases, kallikrein and tissue- plasminogen activator,
- wherein said barrier layer is substantially free of the therapeutic agent, is substantially impervious to and insoluble in wound fluid free of said enzyme and, in use, separates said therapeutic agent from said wound fluid until and unless said substrate is broken down by said enzyme from an infected or chronic wound.
Dependencies are inferred from the claim text.