Process for the purification of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane)
AssigneeHalocarbon Products Corporation
InventorsBarry Jones, Joel Swinson, Paul Mazzell
Life of this patent
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Abstract
A process for purifying crude fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane). The crude sevoflurane is repeatedly washed with water under conditions and for a time sufficient to reduce the level of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) to no more than 200 ppm or no more than 100 ppm.
Claims23
A process for obtaining purified fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) from crude sevoflurane that comprises sevoflurane and more than 200 ppm 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), the process comprising:
- a) combining the crude sevoflurane with water in an amount sufficient to produce a multiphase mixture comprising an aqueous phase and a sevoflurane phase;
- b) contacting the aqueous phase and the sevoflurane phase with each other under conditions and for a period of time sufficient to extract at least a portion of the HFIP from the sevoflurane phase into the aqueous phase;
- c) separating the phases of the multiphase mixture without fractional distillation;
- d) if necessary, repeating steps a) through c) until the level of HFIP in the sevoflurane phase is reduced to no more than 200 ppm;
- and
- e) isolating purified sevoflurane comprising no more than 200 ppm of HFIP;
- wherein the HFIP is removed from the crude sevoflurane without contacting the crude sevoflurane with an aqueous basic solution.
A process for obtaining purified fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane), the process comprising:
- i) producing crude sevoflurane by reacting 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), formaldehyde and hydrogen fluoride (HF);
- ii) reducing the amount of HF in the crude sevoflurane;
- iii) combining the crude sevoflurane with water in an amount sufficient to produce a multiphase mixture comprising an aqueous phase and a sevoflurane phase;
- iv) contacting the aqueous phase and the sevoflurane phase with each other under conditions and for a time sufficient to extract at least a portion of the HFIP from the sevoflurane phase into the aqueous phase;
- v) separating the phases of the multiphase mixture without fractional distillation;
- vi) if necessary, repeating steps iii) through v) until the level of HFIP in the sevoflurane phase is reduced to no more than 200 ppm;
- and
- vii) isolating purified sevoflurane comprising no more than 200 ppm HFIP;
- wherein the HFIP is removed from the crude sevoflurane without contacting the crude sevoflurane with an aqueous basic solution.
A process for obtaining purified fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) from crude sevoflurane that comprises sevoflurane and more than 100 ppm 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), the process comprising:
- a) combining the crude sevoflurane with water in an amount sufficient to produce a multiphase mixture comprising an aqueous phase and a sevoflurane phase;
- b) contacting the aqueous phase and the sevoflurane phase with each other under conditions and for a period of time sufficient to extract at least a portion of the HFIP from the sevoflurane phase into the aqueous phase;
- c) separating the phases of the multiphase mixture without fractional distillation;
- d) if necessary, repeating steps a) through c) until the level of HFIP in the sevoflurane phase is reduced to no more than 100 ppm;
- and
- e) isolating purified sevoflurane comprising no more than 100 ppm of HFIP;
- wherein the HFIP is removed from the crude sevoflurane without contacting the crude sevoflurane with an aqueous basic solution.
Dependencies are inferred from the claim text.