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US 7,732,638 B2Granted
Method of amidocarbonylation reaction
AssigneeJapan Science and Technology Agency
InventorsShu Kobayashi, Ryo Akiyama
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Abstract
A novel method of an amidocarbonylation reaction among an aldehyde compound, an amide compound, and carbon monoxide, which comprises using a palladium-supporting crosslinked-polymer composition containing palladium clusters having a major-axis length of 20 nm or shorter to conduct the amidocarbonylation reaction. Thus, an N-acyl-α-amino acid can be more efficiently and selectively synthesized in a dean reaction system. Also provided is a catalyst for use in the method.
Claims4
In an amidocarbonylation reaction which comprises reacting an aldehyde compound represented by the formula
- where R1 is a hydrogen atom or a hydrocarbon group that may be substituted, with carbon monoxide and an amide compound represented by the formula
- where R2 is a hydrocarbon group that may be substituted, to produce an amino acid compound represented by the formula
- where R1 and R2 are the same as above, the improvement wherein the reaction is conducted in the presence of a palladium-supported crosslinked polymer composition containing a palladium cluster having a major axis of 20 nm or less;
- wherein the said palladium-supported crosslinked polymer composition is one obtained by immobilizing palladium to a copolymer of monomers containing styrene compounds represented by formulas (1), (2) and (3) below
- Where RX and RY are hydrogen atom or a substitution group of formula (1a), at least one of RX and RY being a hydrogen atom,
- n is an integer of 0 to 6, m is an integer of 1 to 6, l is an integer of 0 to 10, Ra is a hydrogen atom or a hydrocarbon group that may be substituted, Rb is a hydrocarbon group that may be substituted, and Ra and Rb may combine with each other to form a lactam ring.
3 more elements
Dependencies are inferred from the claim text.