Amine salt of carbostyril derivative
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsYoshihiro Nishioka, Shinji Aki, Shigekazu Fujita, Yoshinao Onishi, Shun-ichiro Sumida
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Abstract
The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double H bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.
Claims19
An amine salt of a carbostyril derivative comprising 2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid and an amine selected from the group consisting of L-arginine, L-lysine, ethylenediamine, tris(hydroxymethyl) aminomethane, monoethanolamine, diethanolamine, diisopropanolamine, and meglumine.
A pharmaceutical formulation which is prepared in the form of an aqueous solution by adding an aqueous solvent when used, comprising 2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid and an amine selected from the group consisting of L-arginine, L-lysine, ethylenediamine, tris(hydroxymethyl)aminomethene, monoethanolamine, diethanolamine, diisopropanolamine and, meglumine.
Dependencies are inferred from the claim text.