5-(arylsulfonyl)-pyrazolopiperidines

Compounds of the formula:

• stereoisomers, tautomers, mixtures of stereoisomers and/or tautomers or pharmaceutically acceptable salts thereof, wherein
• the A-ring is phenyl or pyridyl, where each ring is optionally substituted at a substitutable position with R10, R11, R12, R13, or R14,
• wherein R10, R11, R12, R13, and R14 are independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, hydroxyl, hydroxyalkyl, CN, —SO2—(C1-C6 alkyl), —NR′R″, C1-C6 alkanoyl, C0-C3alkyl-C(O)OR′, —SO2—NR′R″, where
• each R′ and R″ is independently H or C1-C6 alkyl;
• the B-ring is a pyrazolyl ring which is optionally substituted with one R20 group,
• wherein R20 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, —S(O)0-2R′, hydroxyl, hydroxyalkyl, halo, C1-C2 haloalkyl, C1-C2 haloalkoxy, —NR′SO2R″, —C(O)R′, —CO2R′, —C(O)alkylOC(O)R′, —C(O)NR′R″, CN, or C0-C1alkylaryl;
• and
• R1 is halogen, C1-C6 alkyl, C2-C6 alkenyl, where the alkenyl group is optionally substituted with one or more halogens;
• C2-C6 alkynyl, C3-C6cycloalkyl, C3-C6cycloalkylC1-C6 alkyl, aryl, arylC1-C6 alkyl, heteroaryl, —CO2R′, CONR′R″, C1-C6 haloalkyl, where the haloalkyl group is optionally substituted with C1-C4 alkoxy;
• C1-C4 haloalkoxyalkyl, hydroxy C1-C6 alkyl, C2-C6 alkanoyl, aryloxyC1-C6 alkyl, heteroaryloxy C1-C6 alkyl, —C0-C6 alkyl-OC(O)NR′R″, —C0-C6 alkyl-NR′R″, hydroxyl, or —C0-C6 alkyl-OC(O)-heterocycloalkyl, wherein each aryl, heteroaryl, and heterocycloalkyl group is optionally substituted with one or more groups that are independently halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6alkanoyl, halo C1-C4 alkyl, halo C1-C4 alkoxy, —C(O)NR′R″, —NR′R″, hydroxyl, —O—(CH2)1-2—O—, or —C(O)OR′;
• R1a, R2, and R2a are independently hydrogen, halogen, C1-C6 alkyl, C2-C6 alkenyl, where the alkenyl group is optionally substituted with one or more halogens;
• C2-C6 alkynyl, C3-C6cycloalkyl, C3-C6cycloalkylC1-C6 alkyl, aryl, arylC1-C6 alkyl, heteroaryl, —CO2R′, CONR′R″, C1-C6 haloalkyl, where the haloalkyl group is optionally substituted with C1-C4 alkoxy;
• C1-C4 haloalkoxyalkyl, hydroxy C1-C6 alkyl, C2-C6 alkanoyl, aryloxyC1-C6 alkyl, heteroaryloxy C1-C6 alkyl, —C0-C6 alkyl-OC(O)NR′R″, —C0-C6 alkyl-NR′R″, hydroxyl, or —C0-C6 alkyl-OC(O)-heterocycloalkyl, wherein each aryl, heteroaryl, and heterocycloalkyl group is optionally substituted with one or more groups that are independently halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6alkanoyl, halo C1-C4 alkyl, halo C1-C4 alkoxy, —C(O)NR′R″, —NR′R″, hydroxyl, —O—(CH2)1-2—O—, —C(O)OR′;
• R3, and R3a are independently hydrogen, halogen, or C1-C6 alkyl,
• R1, and R1a, or R3 and R3a combined form ═N—OR, where R is hydrogen, C1-C6 alkyl, aryl or arylalkyl;
• or
• R1, and R1a, or R2 and R2a or R3 and R3a together with the carbon to which they are attached form C3-C6 cycloalkyl group and wherein said ring may be optionally substituted with C1-C6 alkyl.