Tweak receptor
AssigneeImmunex Corporation
InventorSteven R. Wiley
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Abstract
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Claims11
An isolated nucleic acid encoding a monoclonal antibody, wherein said antibody binds to a polypeptide consisting of residues 28 to 68 of SEQ ID NO:4, binds to the extracellular domain of a human TWEAK receptor consisting of the amino acid sequence of SEQ ID NO:4, and inhibits binding of a TWEAK molecule to said TWEAK receptor.
Dependencies are inferred from the claim text.