Modified bacteriocins and methods for their use
AssigneeAvidBiotics Corp.
InventorsDavid W. Martin, Jr., Andrew C. Jamieson, Dean M. Scholl, Steven R. Williams
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Abstract
Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.
Claims24
A nucleic acid molecule encoding a base plate attachment region (BPAR) from an R-type high molecular weight (hmw) bacteriocin tail fiber protein, wherein the BPAR comprises amino acids 1-164 of the N-terminal portion of the R-type bacteriocin tail fiber protein, and a heterologous receptor binding domain (RBD).
Dependencies are inferred from the claim text.