Allergenic latex protein
AssigneeMalaysian Rubber Board
InventorsSiti Arija Mad Ariff, Nyu Ping Chew, Hoong Yeet Yeang
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Abstract
The present invention relates to a protein found in natural rubber that can induce an allergic reaction in persons who have been sensitised to it. The invention provides for the process of isolating and purifying the protein and describes the characteristics of the protein, including its molecular weight, isoelectric point, amino acid sequence and allergenicity. The invention also describes the isolation and cloning a the DNA that encodes the protein. The production of the recombinant version of the protein using a protein expression vector is described.
Claims4
An isolated protein comprising the amino acid sequence of SEQ ID NO:5, wherein said protein is capable of inducing an allergic reaction to latex in a person sensitized to said protein.
An isolated protein capable of inducing an allergic reaction in a person sensitized to said protein, wherein said protein has a molecular weight of about 42,000 Daltons, has an isoelectric point of about 4.7, binds with IgE of patients sensitized to the protein and comprises the amino acid sequence of SEQ ID NO:5.
Dependencies are inferred from the claim text.