Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens
AssigneeInstitut Pasteur
InventorsPaola Minoprio, Mario Arala-Chaves, Antonio Coutinho, Bernardo Reina San Martin, Catherine Rougeot, Wim Degrave, Alain Cosson
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Abstract
A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen, such as a eukaryotic amino acid racemase, in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.
Claims7
A purified polypeptide comprising a polypeptide of Trypanosoma cruzi, wherein the polypeptide of Trypanosoma cruzi is encoded by a nucleic acid sequence wherein the nucleic acid sequence is SEQ ID NO:
- 7.
A purified polypeptide having proline racemase activity comprising a polypeptide of Trypanosoma cruzi, wherein the purified polypeptide is encoded by nucleic acid sequence SEQ ID NO:
- 7 and wherein the catalytic site responsible for the proline racemase activity comprises SEQ ID NO:
- 27.
Dependencies are inferred from the claim text.