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US 7,732,489 B2Granted
Topical emulsion-gel composition comprising diclofenac sodium
AssigneeNovartis AG
InventorMichel Steiger
Life of this patent
Estimating the term…
Abstract
The invention relates to beneficial topical pharmaceutical compositions comprising diclofenac sodium salt in unusually low amounts. The compositions represent opaque emulsion-gels, in which diclofenac is kept fully dissolved.
Claims3
A pharmaceutical topical use in the form of an emulsion gel consisting of:
- (a) 0.1% (w/w) of diclofenac sodium salt,
- (b) 76.57% (w/w) of water,
- (c) 10.0% (w/w) of isopropanol,
- (d) 5.0% (w/w) of propylene glycol,
- (e) 0.7% (w/w) of Carbomer 980,
- (f′) 2.5% (w/w) of liquid paraffin,
- (f″) 2.5% (w/w) of coco-caprylate/caprate,
- (g) 2.0% (w/w) polyoxethylene-20-cetostearyl ether, and
- (h) 0.63% (w/w) ammonia, concentrated solution in water.
6 more elements
A pharmaceutical composition in the form of an emulsion gel for topical use consisting of:
- (a) 0.10% (w/w) of diclofenac sodium salt,
- (b) 74.9% (w/w) of water,
- (d) 15.0% (w/w) of propylene glycol,
- (e) 1.0% (w/w) of Carbomer 974P,
- (f′) 2.5% (w/w) of liquid paraffin,
- (f″) 2.5% (w/w) of coco-caprylate/caprate,
- (g) 2.0% (w/w) polyoxethylene-20-cetostearyl ether,
- (h) 1.5% (w/w) 30% aqueous NaOH solution, and
- (i) 0.5% (w/w) benzyl alcohol.
6 more elements
A pharmaceutical composition in the form of a sprayable emulsion gel consisting of:
- (a) 0.10% (w/w) of diclofenac sodium salt,
- (b) 86.68% (w/w) of water,
- (d) 5.0% (w/w) of propylene glycol,
- (e) 0.3% (w/w) of Carbomer 974P,
- (f′) 2.5% (w/w) of liquid paraffin,
- (f″) 2.5% (w/w) of coco-caprylate/caprate,
- (g) 2.0% (w/w) polyoxethylene-20-cetostearyl ether,
- (h) 0.42% (w/w) 30% aqueous NaOH solution, and
- (i) 0.5% (w/w) benzyl alcohol.
6 more elements
Dependencies are inferred from the claim text.