Use of selective adenosine A1 receptor allosteric enhancers to manipulate angiogenesis
AssigneeUniversity of Virginia Patent Foundation
InventorsJoel Linden, Amy L. Tucker, Richard Price, Rebecca Youkey
Life of this patent
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Abstract
Disclosed is the use of selective adenosine A1 allosteric enhancers to induce angiogenesis at a desired location for treating conditions in which increased angiogenesis is desired, such as stroke, heart disease and peripheral vascular disease.
Claims18
A method of inducing angiogenesis comprising administering to a subject in need thereof an effective angiogenesis inducing amount of an adenosine A1 receptor allosteric enhancer, wherein the subject in need thereof comprises a tissue site having an ischemic injury associated with increased levels of endogenous adenosine.
A composition for inducing angiogenesis comprising an effective angiogenesis inducing amount of an adenosine A1 receptor allosteric enhancer and a pharmaceutically acceptable carrier, wherein the adenosine A1 receptor allosteric enhancer is 7-Oxiranylmethoxy-4,5-dihydro-3H-benzo[b]oxepin-2-one.
A method of inducing angiogenesis comprising administering to a subject in need thereof an effective angiogenesis inducing amount of an adenosine A1 receptor allosteric enhancer, wherein said adenosine A1 receptor allosteric enhancer is [2-Amino-5-bromo-4-(2-naphthyl)-3-thienyl](phenyl)methanone.
A composition for inducing angiogenesis comprising an effective angiogenesis inducing amount of an adenosine A1 receptor allosteric enhancer and a pharmaceutically acceptable carrier, wherein said adenosine A1 receptor allosteric enhancer is [2-Amino-5-bromo-4-(2-naphthyl)-3-thienyl](phenyl)methanone.
A method of inducing angiogenesis comprising administering to a subject in need thereof an effective angiogenesis inducing amount of an adenosine A1 receptor allosteric enhancer, wherein said adenosine A1 receptor allosteric enhancer is 7-Oxiranylmethoxy-4,5-dihydro-3H-benzo[b]oxepin-2-one.
Dependencies are inferred from the claim text.