DNA-PK inhibitors

A compound of formula I:

• and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein:
• R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms;
• Q is —NH—C(═O)— or —O—;
• Y is an optionally substituted C1-5 alkylene group;
• X is SR3, wherein,
• R3 is selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups;
• if Q is —O—, X is additionally selected from NR4R5 and —O(═O)—NR6R7, wherein R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms, and R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms;
• and if Q is —NH—O(═O)—, —Y—X may additionally be selected from C1-7 alkyl.