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US 7,732,480 B2Granted
Bicyclic compounds as modulators of androgen receptor function and method
AssigneeBristol-Myers Squibb Company
InventorsJames J. Li, Lawrence Hamann, Haixia Wang
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Abstract
There are disclosed bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X and n are defined herein.
Claims8
A compound according to formula I:
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is H;
- one R2 at the carbon adjacent to the carbon to which R1 is attached is OH and the other R2's are each H;
- R5 is H;
- X is
- (where N is attached to the bridgehead carbon);
- R6 is selected from the group consisting of G and CH2G;
- G is aryl, wherein said aryl is mono- or polycyclic, and is optionally substituted with one or more substituents selected from the group consisting of hydrogen, halo, CN, alkyl, and substituted alkyl;
- and
- n is 1.
7 more elements
A compound selected from the group consisting of:
- 2-Chloro-4-((3aS,4R ,6aS)-4-hydroxy-2-oxo-hexahydrocyclopenta[b]pyrrol-1(2H)-yl)-3-methylbeuzonitrile;
- and
- 2-Chloro-4-((3aR,4S,6aR)-4-hydroxy-2-oxo-hexahydrocyclopenta[b]pyrrol-1(2H)-yl)-3-methylbenzonitrile.
Dependencies are inferred from the claim text.