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US 7,732,474 B2Granted
Pharmaceutical preparation containing a benzimidazole compound mixed with microcrystalline cellulose and a method for its preparation
Assigneeratiopharm GmbH
InventorsFrank Muskulus, Peter Kraaβ, Andrea Burgenmeister
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Abstract
The present invention relates to oral pharmaceutical preparations in the form of pellets in which a benzimidazole compound is stabilized by combining it with microcrystalline cellulose.
Claims19
An oral pharmaceutical preparation in the form of pellets containing a benzimidazole compound of formula I
- in which R1 is hydrogen, methoxy or difluoromethoxy, R2 is hydrogen, methyl or methoxy, R3 is methoxy, 2,2,2-trifluoroethoxy or 3-methoxypropoxy and R4 is hydrogen, methyl or methoxy, comprising
- (a) an inert core
- (b) to which is applied a layer containing an active ingredient which contains the benzimidazole compound of formula I
- (c) one or more optional separating layers and
- (d) an outer layer comprising an enteric coating,
- wherein the benzimidazole compound of formula I is mixed with a stabilizer comprising microcrystalline cellulose.
3 more elements
A method for improving the stability of a benzimidazole compound of formula I
- in which
- R1 is hydrogen, methoxy or difluoromethoxy,
- R2 is hydrogen, methyl or methoxy,
- R3 is methoxy, 2,2,2-trifluoroethoxy or 3-methoxypropoxy and
- R4 is hydrogen, methyl or methoxy,
- wherein said compound is mixed with a stabilizer comprising microcrystalline cellulose to form a pellet comprising an inert core, an active ingredient layer, one or more optional separating layers and an outer layer comprising an enteric coating.
3 more elements
Dependencies are inferred from the claim text.