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US 7,732,472 B2Granted
Mitotic kinesin inhibitors
AssigneesMerck & Co., Inc., Merck Sharp & Dohme Corp.
InventorsMark E. Fraley, Robert M. Garbaccio, George D. Hartman
Life of this patent
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Abstract
The present invention relates to dihydroisoxazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Claims3
The compound of the Formula III:
- wherein:
- R1 is selected from:
- H, (C═O)a(C1-C6)alkyl, (C1-C6)alkyl-phenyl, (C3-C8)cycloalkyl and (C═O)N(Rd)2;
- R3 is H or (C1-C6)alkyl;
- R5 is halogen;
- Rd is independently selected from H or (C1-C6)alkyl;
- p is 0;
- n is 2;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
6 more elements
Dependencies are inferred from the claim text.