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US 7,732,470 B2Granted
Compositions and methods for the treatment of renal and cardiovascular disease
AssigneesMedical College of Georgia Research Institute, Inc., Board of Regents, The University of Texas System
InventorsJohn D. Imig, John R. Falck
Life of this patent
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Abstract
Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
Claims15
An 11,12-ether epoxyeicosatrienoic acid (EET) derivative compound, wherein the compound has the structural formula:
- or a pharmaceutically acceptable salt thereof, wherein
- n is 1 to 4;
- m is 0 to 3;
- R1 is selected from the group consisting of a linear or branched alkyl and cycloalkyl, each having up to 10 carbon atoms;
- R2, in each occurrence, is selected from the group consisting of linear or branched alkyl, cycloalkyl, alkyloxy, alkylthio, alkylamino, alkenyl, alkoxycarbonyl, carboxyalkylamide, thiazolidinyl-2,4-dione, or heterocyclyl, each optionally substituted with one or more halogen, OH, CO2H, NH2, alkoxy, alkylamine, NO2, SO3alkyl, alkylthio, alkylsulfinyl, or alkylsulfonyl, and each having up to 12 carbon atoms;
- and
- R3 is a C6-9 epoxide;
- wherein the compound reduces blood pressure or hypertension caused by angiotensin II.
5 more elements
Dependencies are inferred from the claim text.