Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists

A compound of formula (I)

• a stereochemically isomeric form thereof, an N-oxide form thereof, or a pharmaceutically acceptable acid or base addition salt thereof, wherein
• —R1—R2— is a bivalent radical of formula
• —O—CH2—CH2—O— (a-3), or
• —O—CH2—CH2—CH2—O— (a-5),
• wherein in said bivalent radicals optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C1-6alkyl or hydroxy,
• R3 is hydrogen, halo, C1-6alkyl or C1-6alkyloxy;
• R4 is hydrogen, halo, C1-6alkyl;
• C1-6alkyl substituted with cyano, or C1-6alkyloxy;
• C1-6alkyloxy;
• cyano;
• amino or mono or di(C1-6alkyl)amino;
• R5 is hydrogen or C1-6alkyl, and the —OR5 radical is situated at the 3- or 4-position of the piperidine moiety;
• L is a radical of formula
• -Alk-R6 (b-1),
• -Alk-X—R7 (b-2),
• wherein each Alk is C1-12alkanediyl;
• and
• R6 is Het;
• R7 is Het;
• X is O, S, SO2 or NR8;
• said R8 being hydrogen or C1-6alkyl;
• and
• Het is morpholinyl;
• morpholinyl substituted with C1-6alkyl;
• tetrazolyl;
• tetrazolyl substituted with halo, hydroxy, or C1-6alkyl;
• pyrazolyl;
• pyrazolyl substituted with halo, hydroxy, or C1-6alkyl;
• isoxazolyl;
• isoxazolyl substituted with halo, hydroxy, or C1-16alkyl;
• isothiazolyl;
• isothiazolyl substituted with halo, hydroxy, or C1-6alkyl;
• 2,4-dioxo-imidazolidinyl;
• 2,4-dioxo-imidazolidinyl substituted with one or two substitutents each independently selected from halo, or C1-6alkyl;
• oxazolyl;
• oxazolyl substituted with halo, hydroxy, or C1-6alkyl;
• thiazolyl;
• thiazolyl substituted with halo, hydroxy, or C1-6alkyl;
• or
• pyranyl;
• pyranyl substituted with halo, hydroxy, or C1-6alkyl.