Pyrido[2,3-B] pyrazin-3(4H)-ones for use as stearoyl CoA desaturase inhibitors

A compound having the structure of Formula I:

• wherein
• R1 is
• a) 4 to 6 membered optionally substituted nitrogen containing monocyclic heterocycle,
• wherein the heterocycle moiety optionally substituted with from 1 to 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkenyl, acyl, acylamino, acyloxy, amino, aminocarbonyl, alkoxycarbonylamino, azido, cyano, halogen, hydroxy, keto, oxo, thiocarbonyl, carboxy, carboxyalkyl, arylthio, heteroarylthio, heterocyclylthio, thiol, alkylthio, aryl, aryloxy, heteroaryl, aminosulfonyl, aminocarbonylamino, heteroaryloxy, heterocyclyl, heterocyclooxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-aryl, —SO-heteroaryl, —SO2—alkyl, SO3-aryl and —SO2-heteroaryl, and
• further wherein each optional alkyl, heteroaryl, aryl, and heterocyclyl substituent is further optionally substituted with halo, NO2, alkyl, CF3, amino, mono- or di-alkylamino, alkyl or aryl or heteroaryl amide, NR20COR22, NR20SO2R22, COR20, CO2R20, CON(R20)2, NR20CON(R20)2, OC(O)R20, OC(O)N(R20)2, S(O)3R20, P(O)(OR20)2, SR20, S(O)R22, SO2R22, SO2N(R20)2, CN, or OR20;
• b) —X—NR4R5,
• c) —X—C(O)NR4R5,
• d) —X—C(O)OR7, or
• e) —X—OR7
• wherein
• R4 is hydrogen or C1-4 lower alkyl, and
• R5 is hydrogen, C1-4 lower alkyl, aryl, heteroaryl, —C1-4 alkoxy, C(═NH)NH2, —C(═O)R6 or —S(═O)2R6, wherein
• R6 is hydrogen, optionally substituted C1-4 alkyl, optionally substituted C1-4 alkenyl, C1-4 alkoxy, 5 or 6 membered optionally substituted monocyclic aryl, or 5 or 6 membered optionally substituted monocyclic heteroaryl, or
• R4 and R5 along with the nitrogen to which they are attached join to form a 5 or 6 membered monocyclic heteroaryl or heteroalkyl ring;
• R7 is hydrogen, optionally substituted C1-4 alkyl, optionally substituted C1-4 alkenyl, 5 or 6 membered optionally substituted monocyclic aryl, or 5 or 6 membered optionally substituted monocyclic heteroaryl,
• X is C2-4 linear or branched alkylene;
• wherein each R6 and R7 alkyl, alkenyl, aryl or heteroaryl moiety is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of alkyl, heterocyclyl, aryl, heteroaryl, halo, NO2, CF3, CN, OR20, SR20, N(R20)2, S(O)R22, SO2R22, SO2N(R20)2, S(O)3R20, P(O)(OR20)2, SO2NR20COR22, SO2NR20CO2R22, SO2NR20CON(R20)2, NR20COR22, NR20CO2R22, NR20CON(R20)2, NR20C(NR20)NHR23, COR20, CO2R20, CON(R20)2, CONR20SO2R22, NR20SO2R22, SO2NR20CO2R22, OCONR20SO2R22, OC(O)R20, C(O)OCH2OC(O)R20, and OCON(R20)2, and
• further wherein each optional alkyl, heteroaryl, aryl, and heterocyclyl substituent is further optionally substituted with halo, NO2, alkyl, CF3, amino, mono- or di-alkylamino, alkyl or aryl or heteroaryl amide, NR20COR22, NR20SO2R22, COR20, CO2R20, CON(R20)2, NR20CON(R20)2, OC(O)R20, OC(O)N(R20)2, S(O)3R20, P(O)(OR20)2, SR20, S(O)R22, SO2R22, SO2N(R20)2, CN, or OR20;
• R2 is optionally substituted aryl, or heteroaryl;
• wherein the aryl or heteroaryl moiety is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of alkyl, heterocyclyl, aryl, heteroaryl, halo, NO2, CF3, CN, OR20, SR20, N(R20)2, S(O)R22, SO2R22, SO2N(R20)2, S(O)3R20, P(O)(OR20)2, SO2NR20COR22, SO2NR20CO2R22, SO2NR20CON(R20)2, NR20COR22, NR20CO2R22, NR20CON(R20)2, NR20C(NR20)NHR23, COR20, CO2R20, CON(R20)2, CONR20SO2R22, NR20SO2R22, SO2NR20CO2R22, OCONR20SO2R22, OC(O)R20, C(O)OCH2OC(O)R20, and OCON(R20)2, and
• further wherein each optional alkyl, heteroaryl, aryl, and heterocyclyl substituent is further optionally substituted with halo, NO2, alkyl, CF3, amino, mono- or di-alkylamino, alkyl or aryl or heteroaryl amide, NR20COR22, NR20SO2R22, COR20, CO2R20, CON(R20)2, NR20CON(R20)2, OC(O)R20, OC(O)N(R20)2, S(O)3R20, P(O)(OR20)2, SR20, S(O)R22, SO2R22, SO2N(R20)2, CN, or OR20;
• R3 is hydrogen, optionally substituted C1-4 alkyl, 6 membered optionally substituted monocyclic aryl, or 5 or 6 membered optionally substituted monocyclic heteroaryl;
• wherein the alkyl, aryl, or heteroaryl moiety is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of alkyl, heterocyclyl, aryl, heteroaryl, halo, NO2, CF3, CN, OR20, SR20, N(R20)2, S(O)R22, SO2R22, SO2N(R20)2, S(O)3R20, P(O)(OR20)2, SO2NR20COR22, SO2NR20CO2R22, SO2NR20CON(R20)2, NR20COR22, NR20CO2R22, NR20CON(R20)2, NR20C(NR20)NHR23, COR20, CO2R20, CON(R20)2, CONR20SO2R22, NR20SO2R22, SO2NR20CO2R22, OCONR20SO2R22, OC(O)R20, C(O)OCH2OC(O)R20, and OCON(R20)2, and
• further wherein each optional alkyl, heteroaryl, aryl, and heterocyclyl substituent is further optionally substituted with halo, NO2, alkyl, CF3, amino, mono- or di-alkylamino, alkyl or aryl or heteroaryl amide, NR20COR22, NR20SO2R22, COR20, CO2R20, CON(R20)2, NR20CON(R20)2, OC(O)R20, OC(O)N(R20)2, S(O)3R20, P(O)(OR20)2, SR20, S(O)R22, SO2R22, SO2N(R20)2, CN, or OR20;
• R20 and R22 are independently selected from the group consisting of hydrogen, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, heterocyclyl, aryl, and heteroaryl,
• wherein the alkyl, alkenyl, alkynyl, heterocyclyl, aryl, and heteroaryl moieties are optionally substituted with from 1 to 3 substituents independently selected from halo, alkyl, mono- or dialkylamino, alkyl or aryl or heteroaryl amide, CN, O—C1-6 alkyl, CF3, aryl, and heteroaryl;
• Q is C1-4 alkylene which may optionally contain one or more —NH—, —O—, —S—, or carbonyl linking moieties;
• W1 is CH;
• and
• W2 is N;
• or a pharmaceutically acceptable salt or ester, thereof.