Thiophene derivatives which are HM74A agonists

A compound of formula (I):

• wherein
• X is O;
• R1 is hydrogen or lower-alkyl;
• R2 is hydrogen, halogen, lower-alkyl or fluoro-lower-alkyl;
• R3 is hydrogen, halogen, lower-alkyl or fluoro-lower-alkyl;
• R4, R5, R6 and R7 independently from each other are hydrogen, halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl or fluoro-lower-alkoxy, or R4 and R5 are bound together to form a cycloalkyl together with the carbon atom to which they are attached and
• —R4—R5— is —(CH2)2-6—, or R6 and R7 are bound together to form a cycloalkyl together with the carbon atom to which they are attached and —R6—R7— is —(CH2)2-6—;
• or;
• R4 and R6 are bound together to form a ring and —R4—R6— is —(CH2)2-6—;
• R8 is aryl or heteroaryl, which aryl or heteroaryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, lower-alkyl, hydroxy-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, carboxy, carboxy-lower-alkyl, lower-alkoxy-carbonyl, lower-alkoxy-carbonyl-lower-alkyl, R10R11NC(O), R10R11NC(O)lower-alkyl, fluoro-lower-alkyl, R10R11N-lower-alkyl, lower-alkyl-SO2, lower-alkyl-SO2O, lower-alkyl-SO2—NR10, R10R11NSO2, cyano, NO2, cycloalkyl, lower-alkoxy-lower-alkyl, lower-alkenyl, lower-alkinyl, fluoro-lower-alkoxy-lower-alkyl, cyano-lower-alkyl, phenyl and heteroaryl, which phenyl or heteroaryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, lower-alkyl-C(O) and lower-alkyl-C(O)N(R10);
• R9 is hydrogen, lower-alkyl or fluoro-lower-alkyl;
• R10 and R11 independently from each other are hydrogen or lower-alkyl;
• m is 0, 1, 2 or 3;
• n is 0, 1, 2 or 3;
• or a pharmaceutically acceptable salt or a pharmaceutically acceptable ester thereof, with the proviso that the compound of formula (I) is not 2-methyl-4-[[(phenylmethoxy)carbonyl]amino]-3-thiophenecarboxylic acid methyl ester, 4-benzoxycarbonylamino-2-methylthiophen-3-carboxylic acid methyl ester, 4-methoxycarbonylamino-2-methylthiophen-3-carboxylic acid methyl ester, 3-(naphth-2-yl)-but-2-enoic acid-N-(3-carboxy-thiophen-4-yl)-amide or 3-(naphth-2-yl)but-2-enoic acid-N-(3-methoxycarbonyl-thiophen-4-yl), and
• with the proviso that if both m and n are 0 and R1 is methyl, then R8 is not nitro-phenyl.