Antifungal ketoconazole composition for topical use
AssigneeBoult Wade Tennant
InventorsMartin Whitefield, Andrew James Dixon, Susan Colette Temple
Life of this patent
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Abstract
A pharmaceutical composition suitable for topical application comprising ketoconazole in a solution which comprises: (i) 13 to 50 wt % water; (ii) 45 to 85 wt % of an alcohol having a boiling point of less than 100° C.; and (iii) 2 to 30 wt % of a non-volatile, water miscible, non-ionic surface active agent; the ketoconazole being present in an amount of 0.5 to 3 st % relative to components (i), (ii) and (iii).
Claims12
A pharmaceutical composition suitable for topical application comprising:
- a true solution comprising:
- (i) 13 to 50 wt % water;
- (ii) 45 to 85 wt % of an alcohol having a boiling point of less than 100° C.;
- and
- (iii) 2 to 30 wt % of a non-volatile, water miscible, non-ionic surface active agent;
- and
- (iv) ketoconazole, the ketoconazole being present in an amount of 1.5 to 2.5 wt % relative to components (i), (ii) and (iii).
A pharmaceutical composition suitable for topical application comprising:
- a true solution comprising:
- (i) 34 to 36 wt % water;
- (ii) 54 to 56 wt % isopropyl alcohol;
- and
- (iii) 9 to 11 wt % polyethoxylated glyceryl cocoate;
- and
- (iv) ketoconazole, the ketoconazole being present in an amount of 1.5 to 2.5 wt % relative to components (i), (ii) and (iii).
A method for making a pharmaceutical composition for the topical treatment of dermatophytosis, cutaneous candidosis, seborrheic dermatitis, tinea capitis, pityriasis capitis, pityriasis versicolor, onychomycosis or pityrosporosis comprising:
- forming a true solution comprising:
- (i) 13 to 50 wt % water;
- (ii) 45 to 85 wt % of an alcohol having a boiling point of less than 100° C.;
- and
- (iii) 2 to 30 wt % of a non-volatile, water miscible, non-ionic surface active agent;
- and
- (iv) ketoconazole, the ketoconazole being present in an amount of 1.5 to 2.5 wt % relative to components (i), (ii) and (iii).
A method for making a pharmaceutical composition for the topical treatment of dermatophytosis, cutaneous candidosis, seborrheic dermatitis, tinea capitis, pityriasis capitis, pityriasis versicolor, onychomycosis or pityrosporosis comprising:
- forming a true solution comprising:
- (i) 34 to 36 wt % water;
- (ii) 54 to 56 wt % isopropyl alcohol;
- and
- (iii) 9 to 11 wt % polyethoxylated glyceryl cocoate;
- and
- (iv) ketoconazole, the ketoconazole being present in an amount of 1.5 to 2.5 wt % relative to components (i), (ii) and (iii).
Dependencies are inferred from the claim text.