US 7,732,442 B2 · Chemokine receptor antagonist and medical use thereof

Abstract

The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc.), and the like], and the like.

Claims3

Dependent claims

A compound represented by formula (I-1) or (I-4):

wherein R1 is selected from the group consisting of halogen atom and methyl which may be substituted by 1 to 3 of halogen atom(s);
m is an integer from 0 to 2;
ring A is a benzene ring, a pyridine ring, a 3,4-dihydro-2H-1,4-benzoxaxazine ring, a 1,2,3,4-tetrahydro-1,8-naphthyridine ring, a quinoline ring, a 1,2,3,4-tetrahydroisoquinoline ring, a pyrazole ring or a thiazole ring which may be substituted by one to three substituent(s) selected from the group consisting of chlorine atom, methoxy, 2-(dimethylamino)ethoxy, piperidin-4-ylmethoxy, 1-methylpiperidin-4-ylmethoxy, methyl, t-butoxycarbonyl and phenyl;
ring B is a benzene ring which may be substituted by one or two substituent(s) selected from the group consisting of halogen atom and methyl which may be substituted by 1 to 3 of halogen atom(s),
or a pharmaceutically acceptable salt thereof.

2 more elements

Dependencies are inferred from the claim text.

Chemokine receptor antagonist and medical use thereof

Life of this patent

Chemokine receptor antagonist and medical use thereof

Life of this patent

Abstract

Claims3