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US 7,732,440 B2Granted
Phenothiazin derivatives, method for the production thereof and use thereof as pharmaceuticals
AssigneeSanofi-Aventis
InventorsStefanie Keil, Elisabeth Defossa, Karl Schoenafinger, Dieter Schmoll, Axel Deitrich, Johanna Kuhlmann-Gottke, Karl-Christian Engel
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of the formula I, wherein R1, R2, R3, R4, R5, R6, R7, A and B are as defined herein, the pharmaceutical compositions and the uses as pharmaceuticals.
Claims18
A compound of formula I
- wherein:
- R1 is H, (C1-C6)-alkyl, (C0-C6)-alkylene-aryl, CO—(C1-C6)-alkyl, (C2-C6)-alkylene-COO—(C0-C6)-alkyl, or (C2-C6)-alkylene-O—(C1-C6)-alkyl;
- R2 and R3 independently of one another are H, F, Cl, Br, CN, NO2, (C0-C6)-alkylene-COO—(C0-C6)-alkyl, (C0-C6)-alkylene-O—(C0-C6)-alkyl, (C1-C6)-alkyl, (C0-C6)-alkylene-CO—(C1-C6)-alkyl, (C0-C6)-alkylene-phenyl, SCF3, SF5, or SCH3;
- R4 and R5 independently of one another are H, F, Cl, Br, CN, SCN, NO2, ═O, (C0-C6)-alkylene-COO—(C0-C6)-alkyl, —CO—COO—(C0-C6)-alkyl, (C0-C6)-alkylene-O—(C0-C6)-alkyl, (C1-C6)-alkyl, (C0-C6)-alkylene-CO—(C1-C6)-alkyl, (C0-C6)-alkylene-CONH(C0-C6)-alkyl, (C0-C6)-alkylene-CON[(C0-C6)-alkyl]2, (C0-C6)-alkylene-NH(C0-C6)-alkyl, (C0-C6)-alkylene-NH—COO—(C0-C6)-alkyl, (C0-C6)-alkylene-CON[(C0-C6)-alkyl]-O—(C0-C6)-alkyl, (C0-C6)-alkylene-N[(C0-C6)-alkyl]2, (C0-C6)-alkylene-aryl, SF5, (C0-C6)-alkyl-S(O)x(C1-C6)-alkyl, S(O)x(C1-C6)-alkylene-COO—(C0-C6)-alkyl, S(O)x(C2-C6)-alkylene-O—(C0-C6)-alkyl, —SO2—NH—(C0-C6)-alkyl, —SO2—N—[(C0-C6)-alkyl]2, S(O)x(C0-C6)-alkylene-heterocycle, S(O)x(C1-C6)-alkylene-CO-heterocycle, —NH—SO2—(C1-C6)-alkyl, (C0-C6)-alkylene-cycloalkyl, (C0-C6)-alkylene-heterocycle, or (C0-C6)-alkylene-aryl;
- x is 0, 1, or 2;
- R6 and R7 independently of one another are H, F, Cl, Br, CN, NO2, ═O, ═S, ═N—O—(C0-C6)-alkyl, (C0-C6)-alkylene-COO—(C0-C6)-alkyl, (C0-C6)-alkylene-O—(C0-C6)-alkyl, (C0-C6)-alkylene-O—CO—(C1-C6)-alkyl, (C1-C6)-alkyl, (C0-C6)-alkylene-CO—(C1-C6)-alkyl, (C0-C6)-alkylene-aryl, SF5, or S(O)x—(C1-C6)-alkyl;
- A is a 5- to 10-membered heterocycle, which may be fused to a further 5- to 10-membered ring;
- and
- B is a 4- to 8-membered cycloalkyl ring, a 4- to 10-membered heterocycle or a 6- to 10-membered aryl ring;
- or a physiologically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.